CrkL, phosphorylated (Tyr207) (Crk-like Protein, v-crk sarcoma virus CT10 oncogene homolog (avian)-like)

Cat no: C7925-50D

Supplier: United States Biological

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Description
Additional Information

CRKL is a 39kD adaptor protein with one SH2 and two SH3 binding domains. CRKL is the major protein which is tyrosine phosphorylated in response to BCR/ABL (chronic myelogenous leukemia) and growth factor activation. In myeloid cells, it binds to proteins such as paxillin, p130cas and p120 cbl. CRKL aslo appears to bind ABL and SOS. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:2000 Optimal dilutions to be determined by the researcher. Positive Control: K562 cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	C7925-50D
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Western Blot
Size:	100ul
Form:	Supplied as a liquid, 0.05% sodium azide.
P type:	Mab
Isotype:	IgG
Purity:	Supernatant.
References:	1. de Jong, R., et. al. (1997). Oncogene. 14: 507-513.
Additional info:	Recognizes phosphorylated human CRKL. Species sequence homology: mouse and rat (100%).

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CrkL, phosphorylated (Tyr207) (Crk-like Protein, v-crk sarcoma virus CT10 oncogene homolog (avian)-like)

Cat no: C7925-50D

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