Crossveinless 2 (CV2, CV-2, CRIM3, BMP-Binding Endothelial Regulator Protein Precursor, BMPER2)

Crossveinless-2 (CV-2), also known as BMPER2 (BMP-binding endothelial regulator), is a secreted glycoprotein that contains a trypsin-inhibitory like domain, five cysteine-rich domains, and a von Willebrand factor type D domain. CV-2 modulates the activity of BMP-2 and BMP-4 in neural crest migration and osteoblast and chondrocyte differentiation. During zebrafish gastrulation, CV-2 is proteolytically cleaved to generate a BMP agonist from a BMP antagonist. Mature human and mouse CV-2 share 93% aa sequence identity. \n\nApplications:\nSuitable for use in Western Blot and ELISA. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1-2ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at 4 degrees C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

C7935-65

Size

100ug

Applications

ELISA, WB

Hosts

Rat

Reactivities

Hum

Form

Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 1ml sterile, ddH2O or sterile 40-50% glycerol.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG2a

Additional Info

Recognizes human Crossveinless-2.