CRTC1 (1B5) Antibody

Cat no: 253035

Supplier: ABBIOTEC

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MECT1 (MucoEpidermoid Carcinoma Translocated 1) is a transcriptional coactivator for CREB1. CREB1 activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. MECT1 is highly e, Xenopus/Amphibian,pressed in adult and fetal brain. Located to specific regions such as the prefrontal corte, Xenopus/Amphibian, and cerebellum. Very low e, Xenopus/Amphibian,pression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.

Catalogue number:	253035
Reactivities:	Human
Applications:	Immunofluorescence
Size:	0.1 ml
Accession:	Q6UUV9
Antigen:	Purified recombinant fragment of human CRTC1 e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	1B5
Additional info:	CREB-regulated transcription coactivator 1; Mucoepidermoid carcinoma translocated protein 1; Transducer of regulated cAMP response element-binding protein 1; TORC-1; Transducer of CREB protein 1; KIAA0616; MECT1; TORC1; WAMTP1; CRTC1

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CRTC1 (1B5) Antibody

Cat no: 253035

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