Home  >  Products  >  CRTH2 (Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CD294, CD294 Antigen, DL1R, G Protein-coupled Receptor, GPCR GPR44, GPR44, Putative G Protein Coupled Receptor 44)
CRTH2 (Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CD294, CD294 Antigen, DL1R, G Protein-coupled Receptor, GPCR GPR44, GPR44, Putative G Protein Coupled Receptor 44)

CRTH2 (Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CD294, CD294 Antigen, DL1R, G Protein-coupled Receptor, GPCR GPR44, GPR44, Putative G Protein Coupled Receptor 44)

Cat no: C7916-05B

Supplier: United States Biological
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CD294 is predominantly expressed on Th2 cells, basophils and eosinophils, and its activation by PDG2 mediates chemotaxis of these cells to inflammatory sites. CD294 may be a useful marker for Th2 cells, and enhances their function and signalling with a possible role in Th2 cell differentiation. PGD2 is thought to contribute to bronchoconstriction, eosinophilia and mucus production in allergic asthma, and CD294 may contribute to this disease. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C7916-05B
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Uller, L. et al. (2007) Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation. Respir. Res. 8: 16.
Additional info: Recognizes human CD294. Species Crossreactivity: rat and mouse.

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