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CRTH2, ID (Chemoattractant receptor-homologous Molecule expressed on Th2 cells, G Protein-coupled Receptor, GPR44)

CRTH2, ID (Chemoattractant receptor-homologous Molecule expressed on Th2 cells, G Protein-coupled Receptor, GPR44)

Cat no: C7916-05E

Supplier: United States Biological
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The chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a recently identified receptor for the prostaglandin D2 (PGD2) in addition to the classic prostaglandin D receptor. CRTH2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, CRTH2- null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the CRTH2-null mice produced significantly higher amounts of interleukin- 5 (IL-5) and IL-3. This suggests that CRTH2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo. At least two different isoforms of CRTH2 are known to exist. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human heart tissue lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C7916-05E
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified
References: 1. Nagata K, et al (1999) FEBS Lett. 459:195-9. 2. Shichijo M, et al (2003) J. Pharmacol. Exp. Ther. 307:518-25. 3. Chevalier E, et al (2005) J. Immunol. 2056-60.
Additional info: Recognizes human CRTH2. Species Crossreactivity: mouse and rat.

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