Crystallin AB (Alpha crystallin B chain, CryAB, Alpha (B)-crystallin, Rosenthal fiber componet, Heat-shock protein beta-5, HspB5, CryA2, AACRYA, Alpha crystallin B chain, CRYA2, Crystallin alpha polypeptide 2, CTPP 2, CTPP2, Heat shock 20kD like protein,

Alpha-crystallin is one of the major structural proteins in the vertebrate eye lenses (2). It occurs as large aggregrates of up to 106 Da composed of two gene products, alphaA-and alphaB-crystallin. These two subunits have a sequence homology of approximately 57%. In humans, the alphaA-crystallin gene encodes a polypeptide of 173 residues and the alphaB-crystallin gene encodes a 175 residue polypeptide. They are related to the small heat proteins (sHsp

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SPECIFICATIONS

Catalog Number

C7944-60

Size

50ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Bov

Form

Serum

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Carver, J.A., Aquilina, J.A., Cooper, P.G., Williams, G.A., Truscott, R.J.W. (1990) \nBiochem. Biophys. Acta 1204: 195-206. \n2. DeJong, W.W., Leunissen, J.A.M., Voorter, C.E.M. (1993) Mol. Biol. Evol. 10: 103-126. \n3. DasGupta, S., Hohman, T.C., Carper, D. (1992) Exp. Eye Res. 54: 461-470. \n4. Inaguma, Y., Shinohara, H., Goto, S., and Kata, K. (1992) Biochem. Biophys. Res. Comm. \n182: 844-850. \n5. Horwitz, J. (1992) PNAS USA 89: 10449-10453. \n6. GenBank Accession #U05569 and #M28638

Additional Info

The antibody Detects a ~20 kD protein, corresponding to the apparent molecular masses of alphaA/alphaB-crystallin on SDS-PAGE immunoblots, in samples from bovine. There is no reactivity with beta-crystallin.