Crystallin, beta, Bovine

The beta-crystallins comprise a complex group of heteropolymers which are assembled from 6 primary gene products, the acidic (betaA1, betaA2, betaA3) and the basic (betaB1, betaB2, betaB3) polypeptides. betaA1 and betaA3 are identical, except for their N-termini, and appear to be generated by alternative translation of the same gene (2,3). betaB1 occurs in two forms, the primary gene product, betaB1a, and betaB1b which is generated through proteolysis (4). Further heterogeneity stems from post-translational modifications such as phosphorylation and/or other modifications that accumulate with aging (5,6). The subunits range in size from 23

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SPECIFICATIONS

Catalog Number

C7944-78

Size

200ug

Applications

WB

Form

Supplied as a liquid in PBS, pH 7.2, 0.15M sodium chloride, 0.05M phosphate buffer.

Purity

(same/more than) 90% by SDS-PAGE

References

1. Augusteyn, R.C., Parkhill, E.M. and Stevens, A. (1992) Exp. Eye Res. 54: 219-228. \n2. G. A. Berbers, W. A. Hoekman, H. Bloemendal, W. W. De Jong, T. Kleinschmidt and G. \nBraunitzer, (1984) Eur. J. Biochem. 139: 467-479. \n3. C. A. Peterson and J. Piatigorsky, (1986) Gene 45: 139-147. \n4. G. A. M. Berbers, W. A. Hoekman, H. Bloemendal, W. W. De Jong, T. Kleinschmidt and \nG. Braunitzer, (1983) FEBS Lett. 161: 225-229. \n5. J. J. Harding and M. J. C. Crabbe, (1984) The Eye (H.Davson, Ed.), 3rd ed., vol. 1b, pp. \n207-492, Academic Press, Orlando, FL. \n6. H. Bloemendal, (1981) Molecular and Cellular Biology of the Eye Lens, Wiley-\nInterscience, New York. \n7. P. Herbrink, H. Van Westreenen and H. Bloemendal, (1995) Exp. Eye Res. 20: 541-548. \n8. J. G. Bindels, A. Koppers and H. J. Hoenders, (1981) Exp. Eye Res. 33: 333-345. \n9. R. J. Siezen, R. D. Anello and J. A. Thomson, (1986) Exp. Eye Res. 43: 293-303.