CSEN (Kv Channel-interacting Protein 3, Kv4 Potassium Channel-interacting Protein, DREAM, KCNIP3, RKChIP3)

There are four member of the KChiPs (Kv4 potassium channel interacting protein) family. They are all EF handcontaining proteins required for the traffic of channelforming Kv4 K+ subunits to the plasma membrane (3). KChiP3 is also known as calsenilin and as the transcription factor, downstream regulatory element antagonist modulator (DREAM), which regulates a number of genes including prodynorphon. They are highly expressed in the hippocampus. Through its various functions, it may play a role in the regulation of synaptic plasticity, learning and memory (4).\n\nApplications: \nSuitable for use in Immunofluorescence, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunofluorescence: 1-10ug/ml\nWestern Blot: 1ug/ml\nImmunohistochemistry: 0.1-1ug/ml\nImmunocytochemistry: 0.1-1ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

136770

Size

100ug

Applications

ICC, IF, IHC, IP, WB

Hosts

Mouse

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, pH 7.4, 50% glycerol.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG2A

References

1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA. 2. Flowerdew S.E., and Burgoyne R.D. (2009) Biochem J. 418(3): 529-540. 3. Alexander J.C., et al. (2009) Learn Mem. 16(3): 167- 177.

Additional Info

Recognizes rat KChlP3 K+ channel at ~34kD. Species Crossreactivity: Human and mouse. No cross reactivity against KCIPs 1,2 or 4.

Alternative Names

Kv Channel-interacting Protein 3, Kv4 Potassium Channel-interacting Protein, DREAM, KCNIP3, RKChIP3