Csf2, Recombinant, Rat (Granulocyte-macrophage Colony-stimulating Factor, GM-CSF, Colony-stimulating Factor, CSF, Csfgm)

GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant rat GM-CSF is a 14.5kD globular protein consisting of 128aa.\n\nSource:\nRecombinant protein corresponding to rat GM-CSF, expressed in E.coli.\n\nBiological Activity:\nDetermined by the dose-dependent stimulation of the proliferation of Murine FDC-P1 cells. The ED50 was found to be <0.01ng/ml \n\nSpecific Activity:\n>1x10e8units/mg.\n\nEndotoxin:\n<0.1ng/ug (1EU/ug)\n\nAA Sequence:\nMAPTRSPNPV TRPWKHVDAI KEALSLLNDM RALENEKNED VDIISNEFSI QRPTCVQTRL KLYKQGLRGN LTKLNGALTM IASHYQTNCP PTPETDCEIE VTTFEDFIKN LKGFLFDIPF DCWKPVQK\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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