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CSK (Tyrosine-protein Kinase CSK, C-Src Kinase, Protein-tyrosine Kinase CYL)

CSK (Tyrosine-protein Kinase CSK, C-Src Kinase, Protein-tyrosine Kinase CYL)

Cat no: C7945-05E

Supplier: United States Biological
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Csk specifically phosphorylates a C-terminal tyrosine on SFKs such as src, fyn and lck, resulting in the down-regulation of kinase activity. Thus, Csk is reported to play an important role in the regulation of cell proliferation and differentiation. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: >1:32,000 Western Blot: 0.5-2ug/ml Immunohistochemistry (paraffin): 0.1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Jurkat Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C7945-05E
Reactivities: Human
Hosts: Goat
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Holtrich U, Brauninger A, Strebhardt K, Rubsamen-Waigmann H. Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase. Proc Natl Acad Sci USA 1991 Dec 1;88(23):10411-5 PMID: 1720539.
Additional info: Recognizes human CSK. Species sequence homology: mouse and rat.

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