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CSL (CBF1, RBP-Jk, J kappa-Recombination Signal-Binding Protein, Suppressor of Hairless, Lag-1)

CSL (CBF1, RBP-Jk, J kappa-Recombination Signal-Binding Protein, Suppressor of Hairless, Lag-1)

Cat no: C7945-35A

Supplier: United States Biological
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RBP-jk, Recombinant signal binding protein for immunoglobin kappa J region, is a human homolog for the Drosophila gene, suppressor of hairless. RBP-jk is located in the nucleus and is a 60kD monomeric protein that is used as a promoter region in notch signaling. Notch signaling is important in cell to cell communication which allows "a differentiating cell to suppress the same differentiation fate in a neighboring cell (the receiving cell). This ensures that the correct number of cells are distributed to distinct cell fates." When RBP-jk is not associated with Notch proteins, it acts as a transcriptional repressor. A disease associated with RBP-jk is the Epstein Barr virus. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Positive Control: HepG2 and mouse liver cell lysates. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C7945-35A
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by ammonium sulfate precipitation.
References: 1. Lendahl, U et al., (1999) Development. 126:3925-3935.
Additional info: Recognizes the Beta-Trefoil Domain of human and mouse RBP-jk. Species sequence homology: Drosophila, Hydra, Horse, rat, Danio, and chicken.

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