Home  >  Products  >  CTAGE1 (Cutaneous T-cell Lymphoma-associated Antigen 1, Protein cTAGE-1, Cancer/Testis Antigen 21.1, CT21.1, CTAGE2, Cutaneous Lymphocyte Antigen, CLA)
CTAGE1 (Cutaneous T-cell Lymphoma-associated Antigen 1, Protein cTAGE-1, Cancer/Testis Antigen 21.1, CT21.1, CTAGE2, Cutaneous Lymphocyte Antigen, CLA)

CTAGE1 (Cutaneous T-cell Lymphoma-associated Antigen 1, Protein cTAGE-1, Cancer/Testis Antigen 21.1, CT21.1, CTAGE2, Cutaneous Lymphocyte Antigen, CLA)

Cat no: C7947-65B

Supplier: United States Biological
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Cutaneous Lymphocyte-assiciated Antigen (CLA) is a 140kD homodimer protein recognized by a unique monoclonal antibody. It is expressed on T lymphocytes in skin, subsets of peripheral blood memory T cells, NK cells, memory B cells and dendritic cells, as well as on monocytes, granulocytes and activated endothelial cells. CLA is a carbohydrate epitope of sialic acid- and fucose-modified P-selectin glycoprotein ligand-1 (PSGL-1), a surface glycoprotein expressed on majority of peripheral blood leukocytes. CLA is a subset ligand for E-selectin, P-selectin, and L-selectin. It plays a role in memory lymphocyte homing, tethering and rolling. Treatment of activated HUVEC cells with this antibody inhibits lymphocyte adhesion. Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)2ug/10e5 cells in 100ul Immunohistochemistry: Acetone-fixed, frozen Immunohistochemistry: Formalin fixed paraffin embedded Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C7947-65B
Reactivities: Human, Mouse
Hosts: Rat
Applications: Flow Cytometry, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgM,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Picker, L. J., et al. 1990. Am. J. Pathol. 136:1053. 2. Berg, E. L., et al. 1991. J. Exp. Med. 174:1461. 3. Fuhlbrigge, R. C., et al. 1997. Nature 389:978. 4. Tu, L., et al. 1999. J. Exp. Med. 189:241. 5. Yoshino, T., et al. 1999. Cell Immunol. 197:39. 6. Chang, SE., et al. 2003. Acta Derm Venereol. 83:162. 7. Schakel, K., et al. 2002. Immunity 17:289. 8. Fuhlbrigge, R. C., et al. 2002. J. Immunol. 168:5645. 9. Duijvestijn, A. M., et al. 1988. Amer. J. Path. 130:147. 10. Picker, L. J., et al. 1991. Nature 349:796. 11. Borges, E., et al. 1997. J. Biol. Chem. 272:28786.
Additional info: Recognizes human Cutaneous Lymphocyte Antigen. Species Crossreactivity: mouse.

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