Home  >  Products  >  Ctf2, Recombinant, Mouse (Cardiotrophin-2, CT-2, Neuropoietin, Np, Gm494, LOC244218)

Ctf2, Recombinant, Mouse (Cardiotrophin-2, CT-2, Neuropoietin, Np, Gm494, LOC244218)

Cat no: 149703


Supplier: United States Biological
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Neuropoietin is a newly identified member of the IL-6 cytokine family. Members of this family, including IL-6, IL-11, oncostatin M, leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, and CNTF, display a four-helix bundle structure, and signal through gp130-containing receptor complexes. Neuropoietin, which is predominantly expressed in neuroepithelia during embryonic life, acts through a receptor complex comprising CNTF receptor-a component, gp 130, and LIF receptor. Like CNTF, it promotes the survival of embryonic motor neurons and could increase the proliferation of neural precursor cells in the presence of EGF and FGF-2. Interestingly, the human Neuropoietin gene has evolved toward a pseudogene, suggesting that the alternative signaling via CNTF is an effective compensatory pathway. Recombinant mouse Neuropoietin is a 19.8kD protein containing 183aa. Source: Recombinant protein corresponding to mouse Neuropoietin, expressed in E.coli. Biological Activity: Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The ED50 was found to be 0.5-0.8ug/ml. Endotoxin: <0.1ng/ug (1EU/ug) AA Sequence: MAPISPSEPI GQAYSLALYM QKNTSALLQT YLQHQGSPFS DPGFSAPELQ LSTLPSAAVS FKTWHAMEDA ERLSRAQGAF LALTQHLQLV GDDQSYLNPG SPILLAQLGA ARLRAQGLLG NMAAIMTALG LPIPPEEDTL GFVPFGASAF ERKCRGYIVT REYGHWTDRA VRDLALLKAK YSA Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: 149703
Size: 5ug
Form: Supplied as a lyophilized powder.
Purity: ~98% (SDS-PAGE and HPLC)

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