CTGF, Recombinant, Human (Connective Tissue Growth Factor, CCN2, Hcs24, Hypertrophic chondrocyte-specific Gene Product 24, IGFBP8, Insulin-like Growth Factor-Binding Protein 8)

Connective Tissue Growth Factor belongs to the CCN family of proteins. The CCN family presently consists of six members in human also known as: Cyr61 (Cystein rich 61), CTGF (Connective Tissue Growth Factor), Nov (Nephroblastoma Overexpressed gene), WISP-1, 2 and 3 (Wnt-1 Induced Secreted Proteins). The CCN genes encode secreted proteins associated with the Extracellular Matrix (ECM) and cell membrane. CCN proteins are matricellular proteins which are involved in the regulation of various cellular functions including: proliferation, differentiation, survival, adhesion and migration. They are expressed in derivatives of the three embryonic sheets and are implicated in the development of kidney, nervous system, muscle, bone marrow, cartilage and bone. During adulthood, they are implicated in wound healing, bone fracture repair, and pathologies such as: fibrosis, vascular ailments and tumorigenesis.\n\nFull length secreted CCN proteins can show an antiproliferative activity, whereas truncated isoforms are likely to stimulate proliferation and behave as oncogenes. The full length protein consists of four modules: Module I shares partial identity with the N-terminal part of the Insulin-like Growth Factor Binding Proteins (IGFBPs). Module II includes a stretch of 70amino acid residues

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SPECIFICATIONS

Catalog Number

C7978-25R

Size

2ug

Form

Supplied as a filtered and lyophilized powder from 0.05M Acetate buffer, pH 4, 4% mannitol, 1% sucrose. Reconstitute with 20ul of 0.1M Acetate buffer, pH 4, and let the pellet dissolve completely.

Purity

(same/more than)95% (SDS-PAGE)

References

1. Lombet, A., et al., Cell Column Signal 1: 1 (2003). 2. Safadi, F.F., et al., J. Cell Phisiol. 196: 51-62 (2003). 3. Abdel-Wahab, N., et al., J. Am. Soc. Nephrol. 13: 2437-2445 (2002).