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CTLA4, Recombinant, Human, aa36-161, His-Tag (Cytotoxic T-lymphocyte Protein 4 Isoform, CD, CD152, CELIAC3, GRD4, GSE, ICOS, IDDM12)

Cat no: 138640

CTLA4, Recombinant, Human, aa36-161, His-Tag (Cytotoxic T-lymphocyte Protein 4 Isoform, CD, CD152, CELIAC3, GRD4, GSE, ICOS, IDDM12)

CTLA4 is a member of the immunoglobulin superfamily and transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. \n\nSource:\nRecombinant protein corresponding to aa36-161 from human CTLA4 at N-terminal, fused to His-tag expressed in E.coli. \n\nMolecular Weight: \n~15.9kD (149aa)\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MGSKAMHVAQ PAVVLASSRG IASFVCEYAS PGKATEVRVT VLRQADSQVT EVCAATYMMG NELTFLDDSI CTGTSSGNQV NLTIQGLRAM DTGLYICKVE LMYPPPYYLG IGNGTQIYVI DPEPCPDSD\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

138640

Size

100ug

Form

Supplied as a liquid in 20mM tris-HCl buffer, pH 8.0, 0.4M urea, 10% glycerol.

Purity

~90% (SDS-PAGE)

References

1. Rudd CE, Taylor A, et al. (2009). Immunol Rev. 229(1):12-26. 2. Stamper CC, Zhang Y, et al. (2001). Nature. 410(6828):608-11.

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Applications

ELISA, FC, IHC, WB

Hosts

Mouse

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Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

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Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Mouse

More info

Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Mouse

More info

Applications

ELISA

Hosts

Mouse

More info
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