CTR1 (copper transporter 1, COPT1, hCTR1, solute carrier family 31 (copper transporters) member 1, SLC31A1)

The trace metal copper (Cu) plays a crucial role in mammalian cells as a cofactor for many enzymes. Cu-related genetic diseases, such as Menkes disease and Wilson disease, arise from a lack of Cu homeostasis in mammalian cells. CTR1 is a high-affinity copper-uptake protein. The C-terminal domain is similar to the Raf family of protein kinases, but it's first two-thirds encodes a novel protein domain. CTR1 provides the primary avenue for copper uptake in mammalian cells, thereby, affecting Cu homeostasis and embryonic development.\n\nPositive Control: Human breast cancer and kidney tissue\n\nApplications: \nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:1000\nImmunohistochemistry (paraffin): 1:250\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

C7948-17

Size

100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Prc, Xen/Amph, ZF/Fish

Form

Supplied as a liquid in Tris-citrate/phosphate, pH 7.5, 0.1% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Holzer, A. K., and Howell, S. B. (2006) The Internalization and Degradation of Human Copper Transporter 1 following Cisplatin Exposure. 66: 10944-10952.

Additional Info

Recognizes human CTR1. Species Crossreactivity: mouse, rat, Xenopus, Zebrafish, and porcine.

Alternative Names

copper transporter 1, COPT1, hCTR1, solute carrier family 31 (copper transporters) member 1, SLC31A1