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CTRP4, CT (Complement C1q Tumor Necrosis Factor-related Protein 4, C1QTNF4)

CTRP4, CT (Complement C1q Tumor Necrosis Factor-related Protein 4, C1QTNF4)

Cat no: C7948-24K

Supplier: United States Biological
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Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-a-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1qcontaining proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. Multiple isoforms of mouse CTRP4 have been reported. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Rat brain cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C7948-24K
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified
References: 1. Fantuzzi G (2005) J. Allergy Clin. Immunol. 115:911-9. 2. Tsao T-S, et al (2004) Euro. J. Pharmacol. 440:213-21. 3. Wong GW, et al (2004) Proc. Natl. Acad. Sci. USA. 101:10302-7. 4. Shapiro L, et al (1998) Curr. Biol. 8:335-8.
Additional info: Recognizes human CTRP4. Species Crossreactivity: mouse and rat.

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