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CTRP5 (C1q and Tumor Necrosis Factor Related Protein 5, C1QTNF5, DKFZP586B0621, FLJ30570, LORD)

Cat no: C7948-25D5

CTRP5 (C1q and Tumor Necrosis Factor Related Protein 5, C1QTNF5, DKFZP586B0621, FLJ30570, LORD)

Mutation to CTRP5 causes it to be retained in the endoplasmic reticulum, and can lead to late-onset retinal degeneration (LORD) and long anterior lens zonules. CTRPs are often highly modified post-translationally, so whereas the predicted molecular weight for CTRP5 is 25kD, AHP1176 detects a single band at 40kD.\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1-5ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

C7948-25D5

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Shu, X. et al. (2006) Disease mechanisms in late-onset retinal macular degeneration associated with mutation in C1QTNF5. Hum. Mol. Genet. 15: 1680-1689. 2. Ayyagari, R. et al. (2005) Late-onset macular degeneration and long anterior lens zonules result from a CTRP5 gene mutation. Invest. Ophthalmol. Vis. Sci. 46: 3363-3371.

Additional Info

Recognizes an epitope within human C1q and TNF related protein 5 (CTRP5). Species sequence homology: mouse and rat.

Alternative Names

Complement C1q Tumor Necrosis Factor Related Protein 5 Precursor

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