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CUEDC2 (CUE Domain-containing Protein 2, C10orf66, HOYS6)

CUEDC2 (CUE Domain-containing Protein 2, C10orf66, HOYS6)

Cat no: C5071-10V1

Supplier: United States Biological
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CUEDC2 is a 287aa protein belonging to the CUEDC2 family with a CUE domain. CUEDC2 is known to interact with PGR and ESR1 with the help of its CUE domain. The exact function of CUEDC2 is yet unknown, but reports suggest that it interacts with PR and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 participates in ubiquitination and subsequent proteasomal degradation of PGR and ESR1 and thus control their protein levels and plays an important role in breast cancer proliferation. Studies on CUEDC2 suggest that it acts as an adaptor protein that interacts with IKK and regulates IKK dephosphorylation by recruiting PP1. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C5071-10V1
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
References: 1. Zhang, PJ. et al. EMBO J. 26:1831-1842 (2007). 2. Strausberg, RL. et al. Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903 (2002). 3. Hui-Yan Li, et al. Nature Immunology. 9:533-541 (2008).
Additional info: Recognizes human CUEDC2. Species sequence homology: mouse, rat, bovine.

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