Cullin 3 (CUL-3)

Cat no: C7949-21B

Supplier: United States Biological

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Description
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Cullins (1, 2, 3, 4a, 5 and 7) are a family of proteins that assemble a large number of ubiquitin ligases to catalyse polyubiquitiation, as well as binding to various specific factors to recruit substrates. Cullin 3 (CUL 3) is involved in the ubiquitination of cyclin E forming a tight complex with this protein which leads to its degradation by proteosomes. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:100 Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	C7949-21B
Reactivities:	Human
Hosts:	Rabbit
Applications:	ELISA, Western Blot
Size:	1mg
Form:	Supplied as a liquid in PBS, pH 7.2.
P type:	Pab
Purity:	Purified by Protein G affinity chromatography.
References:	Du, M. et al. (1998) J. Biol. Chem. 273,24289-24292. Singer, J.D. et al. (1999) Genes & Dev. 13, 2375-2387. Van den Heuvel, S. (2004) Curr. Biol. 14, R59-61. Sumara, I. et al. (2007) Dev. Cell. 12, 887-900.
Additional info:	Recognizes human CUL 3

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Cullin 3 (CUL-3)

Cat no: C7949-21B

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