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Cullin 3 (Cullin-3, CUL3, CUL-3, KIAA0617)

Cullin 3 (Cullin-3, CUL3, CUL-3, KIAA0617)

Cat no: C7949-20G

Supplier: United States Biological
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Cullins are scaffold proteins in the E3 ligase complex and forms a catalytic core complex with Roc1/Rbx1/Hrt1, with Roc1 recruiting a cognate E2 enzyme. They are major components of SCF complexes, and have been implicated in degradation of key regulatory molecules including Cyclin E, beta-catenin and Cubitus interruptus. Six Cul protein members have been identified in mammals: Cul1, Cul2, Cul3, Cul4A, Cul4B, and Cul5. Cullin 3 forms a tight complex with cyclin E and is involved in its ubiquitination, thus regulates G1/S transition. It is also involved in ubiquitination of both BMI1/PCGF4 and H2AFY, in complex with SPOP. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Positive Control: Tonsil Cellular Localization: Nuclear Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C7949-20G
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid in 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Kipreos et al. Cell 85: 829, 1996. 2. Michel et al. Cell Growth & Differentiation 9: 435, 1998. 3. Pagano et al. FASEB 11: 1067, 1997. 4. Jeffrey et al. Genes 13: 2375, 1999.
Additional info: Recognizes human Cullin-3. Species Crossreactivity: mouse.

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