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Cullin 7 (CUL-7, p185, KIAA0076, Cullin homolog 7, p180)

Cullin 7 (CUL-7, p185, KIAA0076, Cullin homolog 7, p180)

Cat no: C7949-22G

Supplier: United States Biological
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Cullins (1, 2, 3, 4a, 5 and 7) are a family of proteins that assemble a large number of ubiquitin ligases to catalyse polyubiquitiation, as well as binding to various specific factors to recruit substrates. Cullin 7 (CUL 7) is a component of SCF-like E3 ubiquitin ligase complex and may play a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. Cullin 7 is a new oncogene that cooperates with Myc in transformation by blocking Myc-induced apoptosis in a p53-dependent manner. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:2000-1:10,000 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C7949-22G
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 100ul
Form: Supplied as a liquid, 0.01% sodium azide.
P type: Pab
Purity: Purified by delipidation and defibrination.
References: 1. Arai, T., et al., (2003), "Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis", Proc. Natl. Acad. Sci., USA, 100 (17), 9855-9860. 2. Dias, D.C., et al., (2002), "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex", Proc. Natl. Acad. Sci., USA, 99 (26), 16601-16606.
Additional info: Recognizes human Cullin 7 at ~191.2kD. Species Crossreactivity: mouse.

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