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Curcumin (Curcuma Longa, 1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane)

Curcumin (Curcuma Longa, 1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane)

Cat no: C7980-80

Supplier: United States Biological
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Cell-permeable. An antioxidant and dual inhibitor of 5-lipoxygenase (IC50=8uM) and cyclooxygenase (COX) (IC50=52uM). Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Also shown to be a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, inhibiting the acetylation of histones H3 and H4 with an IC50 of ~25uM. Does not affect p300/CREB binding protein-associated factor (PCAF). Solubility: DMSO (25mg/ml) or EtOH (10mg/ml) Molecular Weight: ~368.38
Catalogue number: C7980-80
Size: 10mg
Form: Supplied as a orange-yellow solid.
Purity: ~98% (
References: 1. Balasubramanyam, K., et al. (2004). J. Biol. Chem. 279. 51163-51171.

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