Home  >  Products  >  CX3CR1 (CX3C Chemokine Receptor 1, C-X3-C CKR-1, CX3CR1, Beta Chemokine Receptor-like 1, CMK-BRL-1, CMK-BRL1, Fractalkine Receptor, G-protein Coupled Receptor 13, V28, CMKBRL1, GPR13)
CX3CR1 (CX3C Chemokine Receptor 1, C-X3-C CKR-1, CX3CR1, Beta Chemokine Receptor-like 1, CMK-BRL-1, CMK-BRL1, Fractalkine Receptor, G-protein Coupled Receptor 13, V28, CMKBRL1, GPR13)

CX3CR1 (CX3C Chemokine Receptor 1, C-X3-C CKR-1, CX3CR1, Beta Chemokine Receptor-like 1, CMK-BRL-1, CMK-BRL1, Fractalkine Receptor, G-protein Coupled Receptor 13, V28, CMKBRL1, GPR13)

Cat no: C8299-02A

Supplier: United States Biological
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CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, murine, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine (product citation 1). CX3CR1 mediates leukocyte migration and adhesion. CX3CR1 is expressed in a variety of human tissues and cell lines. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:2000 Immunohistochemistry (paraffin): 2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human spleen Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C8299-02A
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Raport CJ, et al. Gene 1995;163:295-9. 2. Combadiere C, et al. DNA Cell Biol 1995;14:673-80. 3. Combadiere C, et al. Biochem Biophys Res Commun 1998;253:728-32. 4. Harrison JK, et al. Neurosci Lett 1994;169:85-9. 5. Imai T, et al. J Biol Chem 1998;273:23799-804.
Additional info: Recognizes human CX3CR1. Species Crossreactivity: mouse and rat.

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