CX3CR1, NT, Blocking Peptide (Beta Chemokine Receptor-like 1, CCRL1, Chemokine C-X3-C Motif Receptor 1, CX3C Chemokine Receptor 1, C-X3-C CKR-1, CX3C CKR-1, CMK-BRL-1, CMKBLR1, CMKDR1, Fractalkine Receptor, GPR13, GPRV28, V28)

Peptide corresponding to aa2-21 of human CX3CR1 (1). The sequence differs from those of mouse and rat CX3CR1 by four amino acids (3,4). CX3CR1 is one of the chemokine receptors that is required as a coreceptor for HIV infection. The genes encoding human, murine, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively, (1-4). The encoded seven transmembrane proteins were recently identified as the receptors for a novel transmembrane molecule, fractalkine, and renamed CX3CR1 (5). Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine (6). CX3CR1 mediates leukocyte migration and adhesion (5). CX3CR1 is expressed in a variety of human tissues and cell lines (2).\n\nAA Sequence: DQFPESVTENFEYDDLAEAC\n\nApplications: \nSuitable for use in ELISA and Antibody Blocking. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability: \nFor long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

C8300P

Size

50ug

Applications

ELISA, WB

Form

Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.02% sodium azide.

References

1. Raport, C.J., et al., Gene 163: 295-299 (1995). 2. Combadiere, C., et al., DNA Cell Biol. 14: 673-680 (1995). 3. Combadiere, C., et al., Biochem. Biophys. Res. Commun. 253: 728-732 (1998). 4. Harrison, J.K., et al., Neurosci. Lett. 169: 85-89 (1994). 5. Imai, T., et al., Cell 91: 521-530 (1997). 6. Combadiere, C., et al., J. Biol. Chem. 273: 23,799-23,804 (1998).