CX3CR1, NT (CX3C Chemokine Receptor 1, C-X3-C CKR-1, Beta Chemokine Receptor-like 1, CMK-BRL-1, CMK-BRL1, Fractalkine Receptor, G-protein Coupled Receptor 13, V28, CMKBRL1, GPR13)

CX3CR1 is one of the chemokine receptors that are required as co-receptors for HIV infection. The genes encoding human, murine, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. Recently, CX3CR1 was found to serve as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine. CX3CR1 mediates leukocyte migration and adhesion. CX3CR1 is expressed in a variety of human tissues and cell lines.\n\nApplications:\nSuitable for use in Immunoprecipitation, Western Blot, Flow Cytometry and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:5000-1:20,000\nWestern Blot: 1:500-1:1000\nImmunohistochemistry: 1: 200\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

C8299-01N

Size

50ug

Applications

ELISA, FC, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Raport, CJ. et al. Gene 163, 295 (1995). 2. Combadiere, C. et al. DNA Cell Biol 14, 673 (1995). 3. Combadiere, C. et al. Biochem Biophys Res Commun 253, 728 (1998). 4. Harrison, JK. et al. Neurosci Lett 169, 85 (1994). 5. Imai, T. et al. Cell 91, 521 (1997). 6. Combadiere, C. et al. J Biol Chem 273, 23799 (1998).

Additional Info

Recognizes human CX3CR1. Species Crossreactivity: mouse and rat.