CXCL5, Recombinant, Mouse (C-X-C Motif Chemokine 5, Cytokine LIX, Small-inducible Cytokine B5, Scyb5)

Chemokine (C-X-C motif) ligand 5 (CXCL5) is a small cytokine belonging to the CXC chemokine family that is also known as epithelial-derived neutrophil-activating peptide 78 (ENA-78). It is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. Expression of CXCL5 has also been observed in eosinophils, and can be inhibited with the type II interferon IFN-?. This chemokine stimulates the chemotaxis of neutrophils possesses angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2. The gene for CXCL5 is encoded on four exons and is located on human chromosome 4 amongst several other CXC chemokine genes. CXCL5 has been implicated in connective tissue remodelling. Epithelial Neutrophil-Activating Protein 78 Mouse Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 93aa and having a molecular mass of 9.8kD.The CXCL5 is purified by proprietary chromatographic techniques.\n\nSource:\nRecombinant corresponding to mouse ENA78 expressed in E. coli.\n\nMolecular Weight:\n~9.8kD\n\nAA Sequence:\nNQGSVAGSCS CDRTISSGTQ IPQGTLDHIR KYLKAFHRCP FFIRFQLQSK SVCGGSQDQW VRELVDCFER KECGTGHGKS FHHQKHLP\n\nBiological Activity: \nDetermined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 10-100ng/ml\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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