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CXCR3 (CD183)

CXCR3 (CD183)

Cat no: C8349-03B

Supplier: United States Biological
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Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Historically, CD183 was the third CXC chemokine receptor discovered and therefore, commonly designated as CXCR3. Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. The CXC chemokine receptor 3 (CXCR3), a G-protein-coupled 7-transmembrane receptor, is expressed at high levels on activated and memory T cells, B cells, natural killer cells, and plasmacytoid monocytes. Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: Paraffin sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C8349-03B
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
Alternative names: CKR-L2, CMKAR3, GPR9, IP10, IP10-R, Mig-R, MigR
References: 1. Wells, T.N., et al., Trends Pharmacol. Sci. 19: 376-380 (1998). 2. Loetscher, M., et al., J. Exp. Med. 184: 963-969 (1996).
Additional info: Recognizes human CXCR3 transfected cells. Does not react with the parent cell line by Flow Cytometry. Does not crossreact with human CXCR1, CXCR2 and CXCR4.

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