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Cyclin A2, CT (Cyclin-A, CCNA2, CCN1, CCNA)

Cyclin A2, CT (Cyclin-A, CCNA2, CCN1, CCNA)

Cat no: C8452-72J

Supplier: United States Biological
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Regulated progression through the cell cycle requires sequential expression of a family of proteins called cyclins. Upon their induction, cyclins form complexes with specific cyclin-dependent kinases (CDKs), creating active holoenzymes that phosphorylate target proteins required for cell-cycle progression. Cyclin A2 (ccna2) is involved in cell cycle control in the S and M phases. One study demonstrated that Cyclin A2 is necessary for visual system development and function. Within humans, Cyclin A is complexed with CDK2 and is a crucial element during S and G2/M phases of the cell cycle, although the mechanism of regulation is not well understood. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Optimal dilutions to be determined by the researcher. Control Peptide: C8452-72P Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C8452-72J
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.1% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Duffy, KT et al (2005) Nucleic Acids Res. 33(15): 4914-4921. 2. Gross, JM et al (2005) Genetics 170(1): 245-261. 3. Tsang, WY et al (2007) J. Cell Biol. 178: 621-633
Additional info: Recognizes zebrafish Cyclin A2.

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