Cyclin C Antibody

Cat no: 250619

Supplier: ABBIOTEC

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Description
Additional Information

Cyclin-C (CCNC) forms the CDK8 module with CDK8,Mouse,ED12,Mouse,ED13, which decreases transcriptional activation when combined with the Mediator comple, Xenopus/Amphibian,. The Mediator comple, Xenopus/Amphibian, is a large protein comple, Xenopus/Amphibian, composed of almost 30 different MED proteins that regulates transcription of nearly all RNA polymerase II (RNApII)-dependent genes, conveying information from gene-specific regulatory proteins. Mediator serves as a scaffold for the assembly of the functional preinitiation comple, Xenopus/Amphibian, that includes RNApII. Cyclin-C-bound CDK8 phosphorylates the C-terminal domain of the large subunit of RNApII, inhibiting the formation of a transcription initiation comple, Xenopus/Amphibian,. Cyclin-C is phosphorylated upon DNA damage,Porcinerobably by ATM or ATR.

Catalogue number:	250619
Reactivities:	Human, Mouse, Bovine, Canine, Chicken/Bird, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P24863
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cyclin C.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit IgG
Additional info:	Cyclin-C; Cyclin C; SRB11; CCNC