Cyclin C

Cat no: C8453-30A

Supplier: United States Biological

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Cyclin C was originally identified by a genetic screen for human and Drosophila cDNAs that complement a triple knock-out of the CLN genes in Saccharomyces cerevisiae. Cyclin C is a nuclear protein present in a multiprotein complex. It interacts both in vitro and in vivo with cdk8, a novel protein-kinase of the cdk family. It is suggested that cyclin C and cdk8 control RNA polymerase II function. Human cdk8-cyclin C might be functionally associated with the mammalian transcription apparatus, perhaps involved in relaying growth-regulatory signals. Cellular Localization: Nuclear Applications: Suitable for use in Immunofluorescence, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	C8453-30A
Reactivities:	Human, Mouse, Rat, Canine
Hosts:	Rabbit
Applications:	Immunofluorescence, Immunoprecipitation, Western Blot
Size:	500ul
Form:	10mM PBS, pH7.4, 0.2% BSA.
P type:	Pab
Isotype:	IgG
Purity:	Purified by Protein A affinity chromatography.
References:	1. Li H; Lahti JM; Kidd VJ. Oncogene, 1996 Aug 15, 13(4):705-12. 2. Yaglom JA; et al. Molecular and Cellular Biology, 1996 Jul, 16(7):3679-84. 3. Demetrick DJ; et al. Cytogenetics and Cell Genetics, 1995, 69(3-4):190-2. 4. Rickert P; et al. Oncogene, 1996 Jun 20, 12(12):2631-40. 5. Tassan JP; et al Proc Natl Acad Sci USA 1995, 92(19):8871-5. 6. Leclerc V; et al. Molecular Biology of the Cell, 1996, 7:505-13.
Additional info:	Species Crossreactivity: Crossreacts with Human, Rat, Mouse and canine.

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Cyclin C

Cat no: C8453-30A

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