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Cyclin D1 Antibody
ABBIOTEC

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ABBIOTEC

Cat no: 251740

Cyclin D1 Antibody

G1/S-specific cyclin-D1 (cyclin D1) is a regulatory component of the cyclin D1-CDK4 (DC) comple, Xenopus/Amphibian, that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F comple, Xenopus/Amphibian, and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Defects in cyclin D1 are a cause of multiple myeloma (MM). MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia.\n

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SPECIFICATIONS

Catalog Number

251740

Size

0.1 mg

Applications

IHC

Reactivities

Hum, Mouse, Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Mouse Monoclonal Antibody

Antigen

Recombinant human cyclin D1 protein.

Isotype

Mouse IgG2a

Accession

P24385

Additional Info

Cyclin D1; G1/S-specific cyclin-D1; PRAD1 oncogene; BCL-1 oncogene; BCL1; PRAD1

SUPPLIER INFO

ABBIOTEC

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