Cyclin D1 Antibody

Cat no: 252030

Supplier: ABBIOTEC

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Description
Additional Information

G1/S-specific cyclin-D1 (cyclin D1) is essential for the control of the cell cycle at the G1/S (start) transition. Cyclin D1 interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme comple, Xenopus/Amphibian,. The cyclin subunit imparts substrate specificity to the comple, Xenopus/Amphibian,. Cyclin D1 interacts with FB, Xenopus/Amphibian,O4 and CDKN1B. Cyclin D1 is ubiquitinated,Porcinerimarily as 'Lys-48'-linked polyubiquitination, by a SCF (SKP1-CUL1-F-bo, Xenopus/Amphibian, protein) ubiquitin-protein ligase comple, Xenopus/Amphibian, containing FB, Xenopus/Amphibian,O4 and CRYAB. Defects in cyclin D1 are a cause of multiple myeloma (MM). MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia.

Catalogue number:	252030
Reactivities:	Human, Mouse, Rabbit
Applications:	Western Blot
Size:	0.1 mg
Accession:	P24385
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human cyclin D 1.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Cyclin D1; G1/S-specific cyclin-D1; PRAD1 oncogene; BCL-1 oncogene; BCL1; PRAD1