Home  >  Products  >  Cyclin D1 (G1/S-specific Cyclin-D1, B-cell Lymphoma 1 Protein, BCL-1, BCL-1 Oncogene, PRAD1 Oncogene, CCND1, BCL1, PRAD1)
Cyclin D1 (G1/S-specific Cyclin-D1, B-cell Lymphoma 1 Protein, BCL-1, BCL-1 Oncogene, PRAD1 Oncogene, CCND1, BCL1, PRAD1)

Cyclin D1 (G1/S-specific Cyclin-D1, B-cell Lymphoma 1 Protein, BCL-1, BCL-1 Oncogene, PRAD1 Oncogene, CCND1, BCL1, PRAD1)

Cat no: C8454-02L

Supplier: United States Biological
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G1:S-specific Cyclin-D1 protein is encoded by the CCND1 gene and it belongs to the highly conserved Cyclin Family. Cyclin family members, including G1/S-specific Cyclin-D1, are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclin-D1 acts as an important regulator of progression from G1 to S phase. Degradation of Cyclin-D1 results in arrest in G1 phase. Accumulation of Cyclin-D1 is regulated at multiple levels including transcription, post-translational activation and cellular localization throughout the cell cycle. Cyclin-D1 also acts to promote cell migration by inhibiting Rho/ROCK signaling and expression of thrombospondin-1 (TSP-1), an extracellular matrix protein that regulates cell migration in many settings including cancer. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis in humans. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 4-6ug/ml Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C8454-02L
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
References: 1. Santra, MK. et al. Nature. 459:722-725 (2009). 2. Gautschi, O. et al. Lung Cancer. 55:1-14 (2007). 3. Li, Z. et al. Cell Cycle. 5:2440-2442 (2007). 4. Gladden, AB. et al. J. Cell. Biochem. 96:906-913 (2005).
Additional info: Recognizes human CCND1. Species Crossreactivity: mouse. Species sequence homology: rat.

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