Cyclin D3 Antibody

Cat no: 251742

Supplier: ABBIOTEC

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Description
Additional Information

Cyclin D3 is a regulatory component of the cyclin D3-CDK4 (DC) comple, Xenopus/Amphibian, that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F comple, Xenopus/Amphibian, and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 comple, Xenopus/Amphibian,es are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3,Porcinehosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary comple, Xenopus/Amphibian,, cyclin D3/CDK4/CDKN1Bovine, required for nuclear translocation and activity of the cyclin D-CDK4 comple, Xenopus/Amphibian,.

Catalogue number:	251742
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P30281
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term/C-term region of human protein.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse Ig
Additional info:	Cyclin D3; G1/S-specific cyclin-D3; CCND3