Cyclin-dependent Kinase 4 (Cdk4)

Cat no: C2574-57

Supplier: United States Biological

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Cyclin-dependent kinase 4 (Cdk4) is a 34kD catalytic subunit of the protein kinase complex and belongs to the Ser/Thr protein kinase family. Cdk4 forms a complex with D-type cyclins and may regulate cell growth during G1 phase of the cell cycle. Cdk4 also associates with Cdk inhibitor p16 that down-regulates Cdk4 activity. Mutations in Cdk4 are associated with tumorigenesis of a variety of cancers. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:250 Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	C2574-57
Reactivities:	Human
Hosts:	Rabbit
Applications:	ELISA, Western Blot
Size:	1mg
Form:	Supplied as a liquid in PBS, pH 7.2.
P type:	Pab
Purity:	Purified by Protein G affinity chromatography.
References:	Khatib, Z.A. et al. (1993) Cancer Res. 53,5535-5541. Pines, J. (1995) Biochem. J. 308,697-711. Bockstaele, L. et al. (2006) Cell Div. 1:25.
Additional info:	Recognizes human Cdk4

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Cyclin-dependent Kinase 4 (Cdk4)

Cat no: C2574-57

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