Home  >  Products  >  Cyclin E (Cyclin-E, CCNE, Cyclin E1, CCNE 1, CCNE1, Cyclin Es, Cyclin Et, G1/S Specific Cyclin E)

Cyclin E (Cyclin-E, CCNE, Cyclin E1, CCNE 1, CCNE1, Cyclin Es, Cyclin Et, G1/S Specific Cyclin E)

Cat no: C8455-01H


Supplier: United States Biological
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Although cyclin E has an important physiological role in normal cell division, recent reports suggest this function is redundant, and its key functions occur as cells exit quiescence, and in endoreduplication. Cyclin E is tightly regulated during normal cell cycles, but is often deregulated in carcinomas, lymphoma, and leukaemia. Applications: Suitable for use in ELISA, Immunoprecipitation and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:2000 Western Blot: 1:200-1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C8455-01H
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Immunoprecipitation, Western Blot
Size: 50ul
Form: Supplied as a liquid, 0.01% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Hwang, H.C. and Clurman, B.E. (2005) Cyclin E in normal and neoplastic cell cycles. Oncogene. 24: 2776-2786. 2. Zhang H. (2007) Life without kinase: cyclin E promotes DNA replication licensing and beyond. Mol. Cell. 25: 175-176.
Additional info: Recognizes human cyclin E. Species Crossreactivity: mouse, rat.

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