Cyclin E2, a 404aa protein, is a member of highly conserved E-type G1-cyclin family. Cyclins bind to and activate CDK kinases to form serine/threonine kinase holoenzyme complexes that regulate eukaryotic cell cycle. Cyclin E2 is localized in the nucleus and shares significant homology with Cyclin E and its expression revolves throughout the cell cycle, with peak expression during G1-S phase. Cyclin E2 binds to and acts as a regulatory subunit of CDK2. It controls the G1-S phase transition during cell cycle and regulates the activity of CIP/KIP family of CDK inhibitors. Its expression is abnormally up-regulated in certain tumors suggesting a possible therapeutic intervention.
Applications:
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution:
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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