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Cyclin H, NT (Cyclin-H, MO15-associated Protein, p34, p37, CCNH)

Cyclin H, NT (Cyclin-H, MO15-associated Protein, p34, p37, CCNH)

Cat no: C8458-02E

Supplier: United States Biological
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Regulated progression through the cell cycle requires sequential expression of a family of proteins called cyclins. Upon their induction, cyclins form complexes with specific cyclin-dependent kinases (CDKs), creating active holoenzymes that phosphorylate target proteins required for cell-cycle progression. In humans, the CDK/Cyclin H complex regulates the CDK-activating kinase (CAK). CAK is involved in activation of RNA polymerase II when complexed with the core-TFIIH basal transcription factor, allowing for elongation of transcripts. However, the function of the Cyclin H ortholog in zebrafish has not yet been isolated. One study has shown Cyclin H to be present throughout early stages of development, and experiments with defective Cyclin H suggest that it plays a vital role in this area. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Control Peptide: C8458-02Q Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C8458-02E
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Shiekhattar, R et al (1995) Nature 374:283-287. 2. Tirode, F et al (1999) Mol. Cell 3:87-95. 3. Liu, Q.Y et al (2007) Cell Res. 17(2):163-173.
Additional info: Recognizes zebrafish Cyclin-H.

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