Cyclophosphamide Monohydrate

Cat no: 007349

Supplier: United States Biological

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It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen. Melting Point: 44-45 degrees C Solubility: Chloroform Method for Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric Analysis Water Content: 7.0% TLC Conditions: SiO2; Dichloromethane: Methanol = 9:1; Visualized with UV, Ninhydrin and KMnO4; Single spot; Rf=0.45 Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.

Catalogue number:	007349
Size:	5g
Form:	Supplied as a white solid.
Purity:	~90%
Alternative names:	N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide Monohydrate; Cycloblastin; Cyclostin; Cytoxan; Endoxan; Genoxal; Hexadrin; Mitoxan; NSC 26271;
References:	Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999),

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Cyclophosphamide Monohydrate

Cat no: 007349

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