A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A?cyclophilin complex that inhibits calcineurin (protein phosphatase 2B).
Storage and Stability:
Lyophilized powder may be stored at 4 degrees C. Stable for 12 months at 4 degrees C. Reconstitute with DMSO or ethanol. Aliquot to avoid repeated freezing and thawing. Store at 4 degrees C. Reconstituted product is stable for 6 months at 4 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.