CYP2B6, ID (CYP2B6, Cytochrome P450 2B6, CYPIIB6, Cytochrome P450 IIB1) (Biotin)

This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\nImmunohistochemistry: 1:50-100\nImmunofluorescence: 1:10-50\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

034432-Biotin

Size

200ul

Applications

ELISA, IF, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Conjugates

Biotin

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Biotin.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Figueroa, S.C., et al. Ther Drug Monit 32(5):579-585(2010)\nChou, M., et al. Antimicrob. Agents Chemother. 54(10):4432-4439(2010)\nShimada, M., et al. Hum. Genet. 128(4):433-441(2010)\nBunten, H., et al. Clin. Pharmacol. Ther. 88(3):383-389(2010)\nGounden, V., et al. AIDS Res Ther 7, 32 (2010) :

Additional Info

Human

Alternative Names

CYP2B6, Cytochrome P450 2B6, CYPIIB6, Cytochrome P450 IIB1