CYP5A1, ID (TBXAS1, CYP5, CYP5A1, Thromboxane-A synthase, Cytochrome P450 5A1) (APC)

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\nImmunohistochemistry: 1:10-50\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

034442-APC

Size

200ul

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Mouse

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Allophycocyanin (APC).

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)\nWang, L.H., et al. Prostaglandins Other Lipid Mediat. 68-69, 409-422 (2002) :\nTazawa, R., et al. Arch. Biochem. Biophys. 334(2):349-356(1996)\nBaek, S.J., et al. Gene 173(2):251-256(1996)\nWang, L.H., et al. Arch. Biochem. Biophys. 315(2):273-278(1994)

Additional Info

Mouse

Alternative Names

TBXAS1, CYP5, CYP5A1, Thromboxane-A synthase, Cytochrome P450 5A1