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CYPB (Peptidyl-prolyl cis-trans Isomerase B, PPIase B, CYP-S1, Cyclophilin B, Rotamase B, S-cyclophilin, SCYLP, PPIB)

CYPB (Peptidyl-prolyl cis-trans Isomerase B, PPIase B, CYP-S1, Cyclophilin B, Rotamase B, S-cyclophilin, SCYLP, PPIB)

Cat no: C8855-01D

Supplier: United States Biological
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Peptidylprolyl isomerase B, also known as Cyclophilin B and PPIB, is a 216aa containing enzyme with peptidyl-prolyl cis-trans isomerase (PPIase) activity and is associated with the secretory pathways and released in biological fluids. It belongs to the cyclophilin-type PPIase family and PPIase B subfamily with a PPIase cyclophilin-type domain and is usually located in the lumen of endoplasmic reticulum and melanosomes. PPIases accelerate the folding of proteins and are known to catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This cyclosporine-binding protein can also bind to cells derived from T- and B-lymphocytes, and is inhibited by the immunosuppressive drug cyclosporin A (CsA) and is hence an important element in the study of CsA-mediated immunosuppression. Reports also suggest that PPIB is an important component of the HCV replication machinery, acting as a stimulatory regulator of NS5B and could be a possible target for antiviral therapy. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C8855-01D
Reactivities: Human, Mouse, Bovine, Canine, Porcine
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Watashi, K. et al. Proc. Nat. Acad. Sci. 88:1903-1907 (1991). 2. Price, ER. et al. Molec. Cell. 19:111-122 (2005). 3. Tryon, RC. et al. Genomics. 90:93-102 (2007).
Additional info: Recognizes human Cyclophilin B. Species Crossreactivity: avian, bovine, chimpanzee, canine, equine, mouse, porcine. Species sequence homology: salmon.

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