CSRP2 (Cysteine-rich protein 2/CRP2; also Cysteine and Glycine-rich protein 2, LMO-5 and SmLIM) is a 21-22kD member of the CRP family of LIM domain-containing proteins. It is expressed in arterial smooth muscle, hepatic stellate cells and fibroblasts. CSRP2 is upregulated by TGF-b and downregulated by PDGF, and appears to interact with PIAS1 and CRP2-BP, thus promoting STAT signaling. It also binds to SRF and GATA4 to initiate smooth muscle differentiation. Human CSRP2 is 193aa in length and contains two 50aa LIM (for lin11/isl1/mec3) domains that contain two zinc-finger motifs (aa10-61 and 119-170), an NLS between aa64-69, and a Gly-rich C-terminus (aa176-187). Full-length human CSRP2 shares 79% aa identity with human CSRP1.
Applications:
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution:
Western Blot:2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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