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Cysteine-rich, Angiogenic Inducer 61 (CYR61)

Cysteine-rich, Angiogenic Inducer 61 (CYR61)

Cat no: C9018-01A

Supplier: United States Biological
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CYR61 is a cysteine-rich, heparin-binding, growth factor belonging to the CCN family of secreted regulatory proteins. It stimulates chondrogensis and angiogenesis, playing an important role in cartilage and bone formation, as well as tumor growth and vascularization. Applications: Suitable for use in Western Blot, Immunofluorescence, Immunocytochemistry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (FFPE): 1:100 Western Blot (ECL): 1:200. A band can be seen at ~37kD representing the processed form of CYR61 protein. Optimal dilutions to be determined by the researcher. Positive Control: MDA-MB-231 breast cancer cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C9018-01A
Reactivities: Human
Hosts: Rabbit
Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: CCN1, GIG1, IGFBP10, Cysteine-rich angiogenic induce 61, insulin-like growth factor-binding protein 10
References: 1. Gashaw I, Stiller S, Boing C, Kimmig R, Winterhager E. Premenstrual Regulation of the Pro-Angiogenic Factor CYR61 in Human Endometrium. Endocrinology. May 1, 2008;149(5):2261-9. (IF, IHC)
Additional info: Recognizes human CYR61. Species sequence homology: rat and mouse 88%.

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