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Cystic Fibrosis Transmembrane Conductance Regulator (CFTR, ABCC7) (BSA & Azide Free)

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR, ABCC7) (BSA & Azide Free)

Cat no: C9040-06A

Supplier: United States Biological
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Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor, a cAMP regulated chloride channel. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (delta F508) which results in abnormal chloride transport. Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is. One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86% and 100% reductions in S. typhi intestinal submucosal uptake. Applications: Suitable for use in Immunocytochemistry, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Immunocytochemistry: 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C9040-06A
Reactivities: Human
Hosts: Rabbit
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS. BSA and sodium azide free.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Pier GB et al. Salmonella typhi uses CFTR to enter intestinal epithelial cells. Nature 393 :79-82 (1998). PubMed: 9590693. 2. Walker J. J Cell Sci: 108:2433-44
Additional info: Recognizes cystic fibrosis transmembrane conductance factor (CFTR) from cells overexpressing the human protein.

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