Cytochrome P450 19A1a, CT (Cyp-19a1a, Aromatase, CYPXIX, Cytochrome P-450AROM, Estrogen Synthase, cyp19a1a, cyp19, cyp19a)

Cat no: C9095-19Z4

Supplier: United States Biological

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Cytochrome p450, family 19 subfamily A polypeptide 1a (Cyp19a1a) was previously known as P450aromA and is one of two isoforms of the aromatase gene. It is the terminal enzyme in the steroidogenic pathway that converts androgens into estrogens. Thus, appropriate expression of the enzyme is essential to both reproduction and sex differentiation. Cyp19a1a is found to be expressed in follicular cells in the ovary during vitellogenesis. One study showed inhibition of cyp19a1a aromatase activity but not transcript abundance when exposed to androstatrienediol. Additionally, expression and aromatase activity of cyp19a1a were inhibited when exposed to estradiol. These results point to the possibility of zebrafish as a model for study of endocrine disrupting molecules. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Control Peptide: C9095-19Z5 Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	C9095-19Z4
Reactivities:	Zebrafish/Fish
Hosts:	Rabbit
Applications:	ELISA, Western Blot
Size:	250ul
Form:	Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type:	Pab
Isotype:	IgG
Purity:	Purified by immunoaffinity chromatography.
References:	1. Kallivretaki, E et al (2006) Mar. Environ. Res. 62 Suppl 1:S187-90. 2. Trant, JM et al (2001) J. Exp. Zool.5-483. 3. Chiang, EF et al (2001) Mol. Biol. Evol. 18(4):542-550. 4. Hinfray, N et al (2006) Environ. Toxicol. 21(4):332-337.
Additional info:	Recognizes zebrafish Cyp19a1a exclusively.

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Cytochrome P450 19A1a, CT (Cyp-19a1a, Aromatase, CYPXIX, Cytochrome P-450AROM, Estrogen Synthase, cyp19a1a, cyp19, cyp19a)

Cat no: C9095-19Z4

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