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Cytochrome P450 2A6 (CYP2A6)

Cytochrome P450 2A6 (CYP2A6)

Cat no: C8929-02A

Supplier: United States Biological
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The Cyp46 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum proein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C8929-02A
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ul
Form: As reported
P type: Pab
Purity: Serum
Alternative names: Cyp46, Cholesterol 24-hydroxylase
References: 1. Brown III, J., et al. Differential Expression of Cholesterol Hydroxylases in Alzheimer's Disease. Journal of Biological Chemistry. 279 (33): 34674-34681, 2004. (Note, rabbit 3046 = NB 400-140)
Additional info: This antibody is specific for Cyp46. Species Crossreactivity: This antibody reacts with human. It does not react with mouse. Other species have not been tested.

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