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Cytochrome P450 2C9, cDNA Probe, Human, BioGenomics(TM)

Cat no: C9095-17M

Cytochrome P450 2C9, cDNA Probe, Human, BioGenomics(TM)

Phase 1 drug metabolism is catalyzed by two groups of monooxygenases, the cytochrome P450s (CYPs) and the flavin monooxygenases (FMOs). Both CYPs and FMOs are localized in the endoplasmic reticulum. Collectively, these enzymes catalyze the oxidation of a very broad range of substrates. Both classes are dependent on NADPH as a source of electrons, but the two classes exhibit significant differences in mechanism and substrate specificity.\n\nSize of the cDNA:\n0.951Kb\n\nApplication:\nSuitable for use for synthesis, by standard random priming or nick translation techniques, of radiolabeled probes for investigations of P450 2C9 gene expression. Other applications not tested.\n\nOptimum dilutions to be determined by researcher.\n\nStorage and Stability:\nAt least one year at -70 degrees C. Avoid repeated freeze thaw cycles.

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SPECIFICATIONS

Catalog Number

C9095-17M

Size

1ug

Form

Supplied in TE buffer.

References

1. Nebert D.W., and Gonzalez, F.J., Ann Rev Biochem., 56: 945 (1987)2. Guengerich F.P., Cancer Research, 48: 2946 (1988)3. Nebert D.W., et al., DNA, 8: 1 (1989)

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